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Biological Significance of the Suppression of Oxidative Phosphorylation in Induced Pluripotent Stem Cells: Cell Reports

Although the primary function of mitochondria is to generate ATP as an energy molecule required for countless cell functions, a small fraction of electrons from the ETC are transferred directly to O 2 , resulting in the generation of the superoxide anion, which can give rise to other ROS as well as reactive nitrogen species (RNS)

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Other Factors Contribute to Health & Disease Some risk factors common for many diseases that can be controlled to some extent include diet, exercise, weight, smoking, stress, and alcohol consumption